Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease
Korean Circulation Journal
; : 395-405, 2020.
Article
en En
| WPRIM
| ID: wpr-816678
Biblioteca responsable:
WPRO
ABSTRACT
Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondrial dysfunction is the root cause for developing heart failure. Therefore, maintenance of mitochondrial quality control (MQC) is an essential process for cardiovascular homeostasis and cardiac health. In this review, we describe the major mechanisms of MQC system, such as mitochondrial unfolded protein response and mitophagy. Moreover, we describe the results of MQC failure in cardiac mitochondria. Furthermore, we discuss the prospects of 2 drug candidates, urolithin A and spermidine, for restoring mitochondrial homeostasis to treat CVD.
Palabras clave
Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Control de Calidad
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Enfermedades Cardiovasculares
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Orgánulos
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Espermidina
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Adenosina Trifosfato
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Causas de Muerte
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Respuesta de Proteína Desplegada
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Mitofagia
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Corazón
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Insuficiencia Cardíaca
Idioma:
En
Revista:
Korean Circulation Journal
Año:
2020
Tipo del documento:
Article