Prevalence of laboratory aspirin resistance in 431 old patients / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 338-342, 2012.
Article
en Zh
| WPRIM
| ID: wpr-814671
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate correlation between and agreement in light transmittance aggregation (LTA) and thromboelastography (TEG) in laboratory diagnosing aspirin resistance (AR), and to determine the prevalence of AR in old patients.@*METHODS@#Patients in the Wanshoulu District of Beijing with ischemic atherothrombotic diseases were recruited. Inclusion criteria were age ≥ 65 years, and having received regular aspirin therapy (75-100 mg daily) for at least 4 weeks. On the basis of LTA assay, the definition of AR was taken as aggregation of ≥ 20% with AA (arachidonic acid), and of ≥ 70% with ADP (adenosine diphosphate). Aspirin-sensitivity was indicated by the absence of either of these criteria; aspirinsensitivity was indicated as both criteria being met. The definition of AR by TEG is ≥ 50% via AA-induced whole blood aggregation.@*RESULTS@#There were 13.69% prevalence of aspirin resistance for LTA using AA as the agonist, 30.16% prevalence of aspirin resistance for LTA using ADP as the agonist, and 23.67% prevalence of aspirin resistance for TEG using AA as the agonist. Results from these tests showed poor agreement (Kappa<0.4). However, by the method of LTA using AA and ADP as the agonists, prevalence of AR was 8.35%. By methods of AA-induced LTA and AA-induced TEG, prevalence of AR was 8.82%. Results from these two latter methods showed good agreement (Kappa = 0.793).@*CONCLUSION@#Combined methods, as described here, have good correlation and agreement in the assays of AR, and the results with them represent a realistic measure of the prevalence of AR. Prevalence of AR of elderly patients from Wanshoulu district of Beijing is about 9%.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Sangre
/
Resistencia a Medicamentos
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Inhibidores de Agregación Plaquetaria
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Trastornos Cerebrovasculares
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Agregación Plaquetaria
/
Aspirina
/
Prevalencia
/
Encuestas y Cuestionarios
/
Enfermedad Coronaria
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Aged
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Female
/
Humans
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Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Año:
2012
Tipo del documento:
Article