Differential expression of DJ-1 and HSP27 in invasive and non-invasive pituitary adenomas / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 481-484, 2012.
Article
en Zh
| WPRIM
| ID: wpr-814647
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore whether oncogenes DJ-1 and HSP27 are associated with invasiveness of human pituitary adenoma.@*METHODS@#Total proteins were extracted from samples of 20 invasive and 20 non-invasive pituitary adenomas and the expression of DJ-1 and HSP27 was analyzed by Western blot. The correlation of DJ-1and HSP27 with the invasiveness of pituitary adenoma was analyzed.@*RESULTS@#The strong positive rates of DJ-1 and HSP27 in the 20 invasive pituitary adenoma were 70% (14/20) and 80% (16/20), respectively. The invasive group had significantly higher expression of DJ-1 and HSP27 proteins than the noninvasive group [10% (2/20), 10% (2/20), respectively]. There was a positive correlation between the expression of DJ-1, HSP27 proteins and the invasiveness of pituitary adenoma as judged by the Spearman rank correlation test (P<0.05).@*CONCLUSION@#The proliferative activity and abnormal expression of oncogenes DJ-1 and HSP27 may play a significant role in tumorigenesis and progression of pituitary adenoma. There was a significant correlation between the expression of DJ-1 and HSP27 and the invasiveness of pituitary adenoma.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Neoplasias Hipofisarias
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Transducción de Señal
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Biomarcadores de Tumor
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Adenoma
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Regulación Neoplásica de la Expresión Génica
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Proteínas Oncogénicas
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Péptidos y Proteínas de Señalización Intracelular
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Proteínas de Choque Térmico HSP27
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Proteína Desglicasa DJ-1
Límite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Año:
2012
Tipo del documento:
Article