Azoospermia factor microdeletion on Y chromosome in patients with idiopathic azoospermia or severe oligozoospermia / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 241-245, 2007.
Article
en Zh
| WPRIM
| ID: wpr-813900
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the correlation between male infertility and Y chromosome microdeletions of azoospermia factor (AZF) regions, and to establish a reliable genetic diagnosis in idiopathic infertile male patients with azoospermia or severe oligozoospermia.@*METHODS@#Multiplex PCR amplification of 6 sequence-tagged sites in AZF regions of the Y chromosome was examined among 100 normal karyotype male patients with azoospermia or oligozoospermia.@*RESULTS@#Four patients (4%) had Y chromosome microdeletions, the microdeletions of 3 patients were idiopathic azoospermic and those of the other 1 patient were secretory azoospermia.@*CONCLUSION@#The PCR-based Y chromosome microdeletion screening is simple and effective in the diagnosis of patients with severe male infertility. Microdeletion of Y chromosome is one of the major causes of severe dyszooospermia.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Oligospermia
/
Deleción Cromosómica
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Proteínas de Plasma Seminal
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Cromosomas Humanos Y
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Diagnóstico
/
Azoospermia
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Sitios Genéticos
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Genética
/
Infertilidad Masculina
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Cariotipificación
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Año:
2007
Tipo del documento:
Article