Effect of mannitol on vasoactive substances / 中南大学学报(医学版)
Zhongnan Daxue xuebao. Yixue ban
; (12): 333-336, 2007.
Article
en Zh
| WPRIM
| ID: wpr-813882
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To observe the changes of vasoactive substances in rabbits administered with mannitol at different dosages and to investigate the mechanism of acute renal failure (ARF) induced by massive mannitol administration.@*METHODS@#Eighteen healthy male New Zealand rabbits were randomly divided into 3 groups: a minor mannitol group (n=6, mannitol 8 g/kg within 2 hours), a control group (n=6, saline of the same volume), and a massive mannitol group with free water taking (n=6, mannitol 40~60 g/kg within 3 days). The changes of renin, angiotensin-I (ang-I), angiotensin-II (ang-II), endothelin (ET), and atrial natriuretic factor(ANF) in the serum were observed.@*RESULTS@#No significant changes in the renin, ang-I, ang-II, ET, and ANF in the serum were found between the minor mannitol group and the saline control group (P> 0.05). In the massive mannitol group with free water taking, renin, ang-I, and ang-II in the serum increased significantly compared with the other 2 groups; ET in the serum decreased significantly compared with the saline control group (P 0.05).@*CONCLUSION@#ARF induced by massive mannitol administration is associated with a significant change of vasoactive substances.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Circulación Renal
/
Sistema Renina-Angiotensina
/
Sangre
/
Angiotensinas
/
Distribución Aleatoria
/
Endotelinas
/
Factor Natriurético Atrial
/
Relación Dosis-Respuesta a Droga
/
Toxicidad
/
Lesión Renal Aguda
Límite:
Animals
Idioma:
Zh
Revista:
Zhongnan Daxue xuebao. Yixue ban
Año:
2007
Tipo del documento:
Article