Effect of yizhi jiannao granule on the behavior and neuron apoptosis in SAMP/8 mice / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 56-59, 2006.
Article
en Zh
| WPRIM
| ID: wpr-813767
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effect of yizhi jiannao granule concentration fluid (YCF) on the behavior, the apoptosis rate of hippocampus neuron and the expression of apoptosis gene Bcl-2, Bax in senescence accelerated mice Senile-Prone/8 (SAMP/8), and to discuss some mechanism of traditional chinese medicine YCF in improving the capability of learning and memory.@*METHODS@#Forty 6-month old SAMP/8 mice were randomly divided into the old group, huperzine A (Hup-A) group and YCF group. Ten 4-month old SAMP/8 mice were served as a young control group. Four groups were given different drugs for 8 weeks, their behavior changes were observed, and the hippocampus were taken out to examine the apotosis rate by flow cytomeutry (FCM) and the expression of Bcl-2, Bax mRNA by RT-PCR.@*RESULTS@#In the YCF group, the escape latency was significantly shortened, the time of swim in the platform quadrant significantly increased, the apoptosis rate of hippocampus neural decreased; the level of Bcl-2 mRNA and the rate of Bcl-2/Bax increased, and the level of Bax mRNA decreased.@*CONCLUSION@#Yizhi jiannao granule can decrease the neuron apoptosis rate and the Bax level, increase the Bcl-2 level, and modulate the rate of Bcl-2/Bax in SAMP/8 brain, which is probably part of the mechanisms of inhibiting the apoptosis and improving learning and memory.
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1
Base de datos:
WPRIM
Asunto principal:
Patología
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Farmacología
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Fisiología
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Conducta Animal
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Envejecimiento
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ARN Mensajero
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Medicamentos Herbarios Chinos
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Distribución Aleatoria
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Apoptosis
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Proteínas Proto-Oncogénicas c-bcl-2
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Año:
2006
Tipo del documento:
Article