Correlation between dynamic contrast-enhanced MRI and expression of microvascular density in the glioma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 686-689, 2005.
Article
en Zh
| WPRIM
| ID: wpr-813448
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore the correlation between microvascular density (MVD) and dynamic contrast-enhanced MRI in the glioma.@*METHODS@#We examined 35 patients with histologically verified glioma. Gadolinium-enhanced dynamic TurboFLASH imaging was performed preoperatively in all patients followed by conventional MRI. The steepest slope (SSmax) of curve and corresponding Tm1 in "first-pass" phase were obtained by analyzing time-signal curve. All specimens were immunostained with anti-human Factor VIII relative antigen monoclonal antibody postoperatively by streptavidin-peroxidase method to obtain the MVD. The correlation between SSmax, Tm1, and MVD was analyzed.@*RESULTS@#SSmax was positively correlated with MVD (r = 0.640, P < 0.01). Tml was negatively correlated with MVD (r = -0.671, P < 0.01).@*CONCLUSION@#The MVD correlates obviously with SSmax and Tml in the glioma. Analyzing the time-signal curve of dynamic contrast-enhanced MRI is helpful to predict the angiogenesis in the glioma.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias Encefálicas
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Imagen por Resonancia Magnética
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Aumento de la Imagen
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Medios de Contraste
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Gadolinio
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Glioma
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Métodos
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Microcirculación
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Neovascularización Patológica
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Año:
2005
Tipo del documento:
Article