Anti-prostate cancer effect of roemerine: An experimental study / 中华男科学杂志
National Journal of Andrology
; (12): 27-33, 2017.
Article
en Zh
| WPRIM
| ID: wpr-812815
Biblioteca responsable:
WPRO
ABSTRACT
Objective@#To investigate the anti-prostate cancer (PCa) effect of roemerine in vitro and in vivo in the mouse model of PCa.@*METHODS@#We detected the effects of roemerine on the proliferation, apoptosis and migration of PCa cells DU145, LNCaP, PC-3 and 22RV1, screened out the sensitive cell line and constructed a tumor-bearing model in mice for verification of the antitumor efficacy of roemerine in vivo.@*RESULTS@#Roemerine inhibited the proliferation and migration of the DU145, LNCaP, PC-3 and 22RV1 cells and induced their apoptosis in different degrees, particularly those of the LNCaP cells. The average tumor weight was less in the roemerine intervention group (［1.99±0.95］ g) than in the control (［2.95±1.04］ g), the least in the high-dose roemerine (30 mg/kg) plus paclitaxel intervention group (［0.90±0.16］ g). The mean heart, liver, and kidney indexes were markedly lower in the roemerine (0.58±0.06, 6.20±0.42 and 1.49±0.33) than in the paclitaxel group (0.66±0.04, 6.99±0.72 and 1.95±0.34), while the mean spleen and thymus indexes were remarkably higher in the former (0.54±0.11 and 0.06±0.01) than in the latter (0.41±0.09 and 0.05±0.01). Pathological staining showed a lower degree of malignancy and metastasis in both the roemerine and the roemerine + paclitaxel intervention group than in the control, as well as a lower degree of visceral injury in the roemerine and roemerine + paclitaxel groups than in the paclitaxel group.@*CONCLUSIONS@#Roemerine has some anti-PCa effect and alleviates adverse reactions in paclitaxel combination administration.
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Base de datos:
WPRIM
Asunto principal:
Neoplasias de la Próstata
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Medicamentos Herbarios Chinos
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Movimiento Celular
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Paclitaxel
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Apoptosis
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Línea Celular Tumoral
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Usos Terapéuticos
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Proliferación Celular
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Modelos Animales de Enfermedad
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Quimioterapia
Límite:
Animals
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2017
Tipo del documento:
Article