Pleurotus nebrodensis polysaccharide (PN-S) enhances the immunity of immunosuppressed mice / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 760-766, 2015.
Article
en En
| WPRIM
| ID: wpr-812485
Biblioteca responsable:
WPRO
ABSTRACT
In the present study, the effects of Pleurotus nebrodensis polysaccharide (PN-S) on the immune functions of immunosuppressed mice were determined. The immunosuppressed mouse model was established by treating the mice with cyclophosphamide (40 mg/kg/2d, CY) through intraperitoneal injection. The results showed that PN-S administration significantly reversed the CY-induced weight loss, increased the thymic and splenic indices, and promoted proliferation of T lymphocyte, B lymphocyte, and macrophages. PN-S also enhanced the activity of natural killer cells and increased the immunoglobulin M (IgM) and immunoglobulin G (IgG) levels in the serum. In addition, PN-S treatment significantly increased the phagocytic activity of mouse peritoneal macrophages. PN-S also increased the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ (INF-γ), and nitric oxide (NOS) in splenocytes. qRT-PCR results also indicated that PN-S increased the mRNA expression of IL-6, TNF-α, INF-γ, and nitric oxide synthase (iNOS) in the splenocytes. These results suggest that PN-S treatment enhances the immune function of immunosuppressed mice. This study may provide a basis for the application of this fungus in adjacent immunopotentiating therapy against cancer and in the treatment of chemotherapy-induced immunosuppression.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fagocitosis
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Farmacología
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Polisacáridos
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Productos Biológicos
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Línea Celular
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Química
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Terapia de Inmunosupresión
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Interleucina-6
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Interferón gamma
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Factor de Necrosis Tumoral alfa
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2015
Tipo del documento:
Article