Mixed nanomicelles loaded with thymopeptides-sodium deoxycholate/phospholipid improve drug absorption / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 65-70, 2014.
Article
en En
| WPRIM
| ID: wpr-812307
Biblioteca responsable:
WPRO
ABSTRACT
AIM@#To improve the absorption of thymopeptides (TH) by preparing sodium deoxycholate/phospholipid-mixed nanomicelles (SDC/PL-MMs).@*METHODS@#TH-SDC/PL-MMs were prepared by a film dispersion method, and then evaluated using photon correlation spectroscopy (PCS), zeta potential measurement, as well as their physical stability after storage for several days. Furthermore, in situ intestinal single-pass perfusion experiments and pharmacodynamics in immunodeficient mice were performed to make a comparison with TH powders and the control drug in absorption properties.@*RESULTS@#A narrow size distribution of nanomicelles, with a mean particle size of (149 ± 8.32) nm and a zeta potential of (-31.05 ± 2.52) mV, was obtained. The in situ intestine perfusion experiments demonstrated a significant advantage in absorption characteristics for TH compared to the other formulations, and oral administration of TH-SDC/PL-MMs potentiated an equivalent effect with i.h. TH in pharmacodynamic studies in immunodeficient mice.@*CONCLUSIONS@#TH-SDC/PL-MMs prepared by a film dispersion method are able to improve the absorption of TH. SDC/PL-MMs might be a good approach for the more effective delivery of drugs like TH.
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Tamaño de la Partícula
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Péptidos
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Fosfolípidos
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Timo
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Portadores de Fármacos
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Farmacocinética
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Química
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Química Farmacéutica
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Ratas Wistar
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Ácido Desoxicólico
Límite:
Animals
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En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2014
Tipo del documento:
Article