Expression and role of SOCS-3 and associated cytokines in HIV/TB coinfection / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 515-518, 2017.
Article
en Zh
| WPRIM
| ID: wpr-808823
Biblioteca responsable:
WPRO
ABSTRACT
Objective@#To investigate the expression levels and clinical significance of serum suppressor of cytokine signaling-3 (SOCS3) and associated cytokines in HIV/TB co-infected patients.@*Methods@#The serum levels of SOCS3, IFN-γ, IL-2, IL-4, IL-6, IL-10, IL-17 and IL-22 were quantified by using enzyme-linked immunosorbent assays (ELISA) in 50 HIV-infected patients, 48 HIV/TB co-infected patients and 50 healthy donors. Pearson correlation analysis was used to analyze the correlation between SOCS3 and other seven cytokines.@*Results@#Serum levels of SOCS3 expression in HIV/TB co-infection group were significantly higher than those in HIV-infection alone and the control group. There was also significant correlation between SOCS3 and IFN-γ, IL-4, IL-6, IL-10, IL-2 in HIV/TB co-infection group.@*Conclusions@#These findings indicated that SOCS3 may play an important role in the immune response of patients with HIV/TB co-infection and it may be helpful in the diagnosis of HIV/TB co-infection.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2017
Tipo del documento:
Article