The efficacy and safety of denosumab and bisphosphonates on glucocorticoid induced osteoporosis patients:a meta-analysis / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 869-874, 2019.
Article
en Zh
| WPRIM
| ID: wpr-797096
Biblioteca responsable:
WPRO
ABSTRACT
Objective@#In order to evaluate the therapeutic effects and safety of denosumab and bisphosphonates in glucocorticoid induced osteoporosis patients.@*Methods@#Standard studies were obtained by searching CNKI, CBM, VIP, Wanfang, Pubmed, Embase and Cochrane databases.@*Results@#Three RCTs with 869 patients were included in this study. It showed that the mean changes of lumbar spine, total hip and femoral neck bone mineral density (BMD) for patients in denosumab group were increased by 2.47%, 1.43% and 1.07% respectively compared to those of bisphosphonates group.There was no statistically significant difference between patients receiving denosumab and those receiving bisphosphonate in terms of adverse events and serious adverse events.@*Conclusions@#Denosumab has an effective increase for lumbar spine, total hip and femoral neck bone mineral density, and the safety of both is similar.
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1
Base de datos:
WPRIM
Tipo de estudio:
Systematic_reviews
Idioma:
Zh
Revista:
Chinese Journal of Postgraduates of Medicine
Año:
2019
Tipo del documento:
Article