Oxidized meosporous carbon nanospheres as carriers for paclitaxel / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 114-118, 2015.
Article
en Zh
| WPRIM
| ID: wpr-790423
Biblioteca responsable:
WPRO
ABSTRACT
Objective To prepare oxidized mesoporous carbon nanospheres and investigate potential application as drug delivery carriers for paclitaxel .Methods Physicochemical properties such as morphology ,diameter ,pore diameter and pore volume were characterized .Drug‐loading capacity was measured and drug release behavior in vitro was investigated by dialysis method .In vitro antitumour effect was evaluated by CCK‐8 methods .Results The synthesized oxidized mesoporous carbon nanospheres had an average diameter of 140 nm ,Zeta potential of -36 mV ,high specific surface area of 704.63 m2/g ,high drug‐loading capacity of 45 .6% .Conclusion Oxidized mesoporous carbon nanospheres have promising application in anti‐cancer drug delivery system .
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1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Pharmaceutical Practice
Año:
2015
Tipo del documento:
Article