Roles and mechanisms of chemokine CX3CL1 in cerebral ischemia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 706-710, 2019.
Article
en Zh
| WPRIM
| ID: wpr-789100
Biblioteca responsable:
WPRO
ABSTRACT
Chemokine CX3CL1 mainly participates in the physiological and pathological processes of nervous system by activating its receptor CX3CR1.Under physiological conditions,CX3CL1 can inhibit the activation of microglia;when cerebral ischemia and hypoxia,CX3CL1 can affect the expression of multiple downstream target genes involved in activation of adenosine receptor,inhibition of Ca 2+ influx,and promotion of blood vessel growth.It is of great significance to improve the energy metabolism disorder and to establish microcirculation around infarcts after cerebral ischemia.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
International Journal of Cerebrovascular Diseases
Año:
2019
Tipo del documento:
Article