Biodegradable Screws Containing Bone Morphogenetic Protein-2 in an Osteoporotic Rat Model
Journal of Korean Neurosurgical Society
; : 559-567, 2018.
Article
en En
| WPRIM
| ID: wpr-788723
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: The aim of this study was to evaluate the effect for biodegradable screws containing bone morphogenetic protein-2 (BMP-2) in an osteoporotic rat model.METHODS: Twenty-four female Wistar rat (250–300 g, 12 weeks of age) were randomized into four groups. Three groups underwent bilateral ovariectomy (OVX). Biodegradable screws with or without BMP-2 were inserted in the proximal tibia in two implantation groups. The extracted proximal metaphysis of the tibiae were scanned by exo-vivo micro-computed tomography. Evaluated parameters included bone mineral density (BMD), trabecular bone volume (BV/TV), trabecular number, trabecular thickness, and trabecular separation (Tb.Sp). The tibia samples were pathologically evaluated by staining with by Hematoxylin and Eosin, and trichrome.RESULTS: Trabecular formation near screw insertion site was evident only in rats receiving BMP-2 screws. BMD and BV/TV significantly differed between controls and the OVX and OVX with screw groups. However, there were no significant differences between control and OVX with screw BMP groups. Tb.Sp significantly differed between control and OVX and OVX with screw groups (p < 0.05), and between the OVX and OVX with screw BMP group (p < 0.05), with no statistically significant difference between control and OVX with screw BMP groups. Over the 12 weeks after surgery, bone lamellae in direct contact with the screw developed more extensive and thicker trabecular bone around the implant in the OVX with screw BMP group compared to the OVX with screw group.CONCLUSION: Biodegradable screws containing BMP-2 improve nearby bone conditions and enhance ostoeintegration between the implant and the osteoporotic bone.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Osteoporosis
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Tibia
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Ovariectomía
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Densidad Ósea
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Eosina Amarillenta-(YS)
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Modelos Animales
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Proteína Morfogenética Ósea 2
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Hematoxilina
Tipo de estudio:
Clinical_trials
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Journal of Korean Neurosurgical Society
Año:
2018
Tipo del documento:
Article