A Case of 47-Years-Old Female with Obstructive Jaundice and Weight Loss / 대한소화기암학회지
Journal of Digestive Cancer Report
; (2): 18-21, 2019.
Article
en En
| WPRIM
| ID: wpr-787284
Biblioteca responsable:
WPRO
ABSTRACT
Serine protease inhibitor Kazal-type 1 (SPINK1) is a gene expressed from pancreatic acinar cell which its mutation is known to be associated with chronic pancreatitis (CP) and pancreatic cancer. We report a case of a 47-years-old female with nausea and weight loss with yellow discoloration of skin. Initial imaging and endoscopic study led us to an impression of chronic pancreatitis with pancreatic cancer with common bile-duct dilation. Biopsy result was confirmed with pancreatic adenocarcinoma and additional imaging revealed lymph node and bone metastasis. Our genetic analysis revealed 194+2T>C mutation of SPINK1. Biliary obstruction was successfully decompressed by stent insertion and underwent chemotherapy and radiotherapy. Although there is accumulating evidence of association between SPINK1 mutation and CP, the relationship between SPINK1 mutation and pancreatic cancer in CP patient is an emerging concept. Genetic analysis should be considered in patients with young age especially when diagnosed with both CP and pancreatic cancer.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias Pancreáticas
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Radioterapia
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Piel
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Biopsia
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Adenocarcinoma
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Pérdida de Peso
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Stents
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Genes vif
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Ictericia Obstructiva
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Quimioterapia
Límite:
Female
/
Humans
Idioma:
En
Revista:
Journal of Digestive Cancer Report
Año:
2019
Tipo del documento:
Article