Correlates of the Severity of Coronary Atherosclerosis in Long-term Kidney Transplant Patients
Journal of Korean Medical Science
; : 706-711, 2010.
Article
en En
| WPRIM
| ID: wpr-77809
Biblioteca responsable:
WPRO
ABSTRACT
Coronary artery disease remains the leading cause of early death and graft loss in renal transplant patients. The aim of this study was to identify clinical and echocardiographic parameters independently associated with the angiographically-determined severity of coronary atherosclerosis in long-term kidney transplant patients. Fifty-two kidney transplant recipients who underwent elective coronary angiography were reviewed retrospectively. Angiographic severity was evaluated using the modified Gensini index (MGI). The mean age at coronary angiography was 52.5+/-7.9 yr with a mean prior transplant duration of 118.1+/-58.8 months. Pearson correlation analysis demonstrated a positive correlation of MGI with transplant duration before coronary angiography and chronic allograft nephropathy, whereas an inverse correlation was demonstrated with ejection fraction and statin use. On subsequent multivariate linear regression analysis, transplant duration before coronary angiography, statin use, and ejection fraction were independently associated with the severity of coronary atherosclerosis in long-term kidney transplant patients. In summary, our study demonstrates that statin use, ejection fraction, and transplant duration before coronary angiography are independent parameters associated with the severity of coronary atherosclerosis in long-term kidney transplant patients. Further investigation is required to reduce the atherosclerotic burden in kidney transplant patients.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Enfermedad de la Arteria Coronaria
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Comorbilidad
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Incidencia
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Factores de Riesgo
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Estadística como Asunto
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Trasplante de Riñón
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Medición de Riesgo
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Insuficiencia Renal
/
Corea (Geográfico)
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2010
Tipo del documento:
Article