The association between IGF1 gene rs1520220 polymorphism and cancer susceptibility: a meta-analysis based on 12,884 cases and 58,304 controls
Environmental Health and Preventive Medicine
; : 38-38, 2018.
Article
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| WPRIM
| ID: wpr-777667
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND@#The rs1520220 polymorphism in the insulin-like growth factor 1 (IGF1) gene has been reported to affect cancer susceptibly in several studies. However, the results of the relevant studies are inconsistent. We conduct a current meta-analysis to investigate the association between rs1520220 and cancer susceptibly.@*METHODS@#Three databases (PubMed, Embase, and Web of Science) were searched for studies regarding the relationship between rs1520220 and cancer susceptibly. Odds ratios (ORs) and the related 95% confidence intervals (CIs) were employed to assess the strength of the associations. A stratified analysis was performed according to cancer type, ethnicity, and quality score, and when results were obtained from no fewer than two studies, these results were pooled.@*RESULTS@#There was no positive association between rs1520220 and overall cancer risk. However, the analysis stratified by ethnicity revealed that rs1520220 significantly increased cancer susceptibility in Asian populations (allele model OR = 1.10, 95%Cl = 1.00-1.21, p = 0.040; homozygote model OR = 1.22, 95%Cl = 1.01-1.47, p = 0.040; dominant model OR = 1.19, 95%Cl = 1.01-1.39, p = 0.033). No significantly association was detected in Caucasian populations. The analysis stratified by cancer type suggested that rs1520220 was not associated with susceptibility to breast cancer.@*CONCLUSIONS@#The results of our meta-analysis demonstrate that the role of IGF1 rs1520220 in cancer susceptibility varies by ethnicity and cancer type and that rs1520220 increases cancer susceptibility in Asian populations.
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Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
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Oportunidad Relativa
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Grupos Raciales
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Pueblo Asiatico
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Etnología
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Frecuencia de los Genes
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Genética
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Neoplasias
Tipo de estudio:
Etiology_studies
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Prognostic_studies
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Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Environmental Health and Preventive Medicine
Año:
2018
Tipo del documento:
Article