Role of prostaglandin E receptor EP4 in the regulation of adipogenesis and adipose metabolism / 生理学报
Acta Physiologica Sinica
; (6): 491-496, 2019.
Article
en Zh
| WPRIM
| ID: wpr-777163
Biblioteca responsable:
WPRO
ABSTRACT
Adipose tissue is the energy storage organ of the body, and excess energy is stored in adipocytes in the form of lipid droplets. The homeostasis of adipose tissue is the basis for the body to maintain normal metabolic activity. Prostaglandin E (PGE) is an important lipid mediator in the body. It is synthesized in almost all tissues and participates in the regulation of many physiological processes such as blood pressure, glucose and lipid metabolism, and inflammation. PGE is abundant in white adipose tissue, where it is involved in the regulation of fat metabolism. PGE plays its biological role through binding to four G protein coupled receptors (prostaglandin E receptors), including EP-1, -2, -3, and -4. The EP4 subtype has been proved to play an important role in adipogenesis and adipose metabolism: it could inhibit adipogenesis while it was activated, whereas its knockout could promote lipolysis. This review summarized the relationship between EP4 and adipose metabolism, hoping to identify new targets of drug development for metabolic disorders.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fisiología
/
Tejido Adiposo
/
Adipocitos
/
Adipogénesis
/
Subtipo EP4 de Receptores de Prostaglandina E
/
Metabolismo
Límite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Año:
2019
Tipo del documento:
Article