Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 456-464, 2018.
Article
en En
| WPRIM
| ID: wpr-773596
Biblioteca responsable:
WPRO
ABSTRACT
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
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Ensayos de Selección de Medicamentos Antitumorales
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Medicamentos Herbarios Chinos
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Estructura Molecular
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Química
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Lipopolisacáridos
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Cristalografía por Rayos X
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Células HL-60
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Resonancia Magnética Nuclear Biomolecular
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Isodon
Límite:
Animals
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Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2018
Tipo del documento:
Article