Platelet membrane-based and tumor-associated platelettargeted drug delivery systems for cancer therapy / 医学前沿
Frontiers of Medicine
; (4): 667-677, 2018.
Article
en En
| WPRIM
| ID: wpr-772715
Biblioteca responsable:
WPRO
ABSTRACT
Platelets have long been known to play critical roles in hemostasis by clumping and clotting blood vessel injuries. Recent experimental evidence strongly indicates that platelets can also interact with tumor cells by direct binding or secreting cytokines. For example, platelets have been shown to protect circulating cancer cells in blood circulation and to promote tumor metastasis. In-depth understanding of the role of platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatment. This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated platelets for cancer therapy. The paper also discusses future development opportunities and challenges encountered for clinical translation.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
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Plaquetas
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Portadores de Fármacos
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Química
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Modelos Animales
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Biología Celular
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Materiales Biomiméticos
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Nanoestructuras
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Quimioterapia
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Nanomedicina
Límite:
Animals
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Humans
Idioma:
En
Revista:
Frontiers of Medicine
Año:
2018
Tipo del documento:
Article