OBJECTIVE@#To survey and analyze the allergic rhinitis patients' allergens in developed region of Pearl River Delta and developing region out of Pearl River Delta in Guangdong.@*METHOD@#Sixteen standard allergens were adopted for skin prick test and correlation factors were studied on 858 cases suspected allergic rhinitis from developed region of Pearl River Delta and developing region out of Pearl River Delta. Two regions patients sorts of allergen and their detection rate were compared, and the relationship between allergen positive rate and age, gender, body weight, family history was analyzed.@*RESULT@#The 6 kinds allergen with higher positivity in developed region of Pearl River Delta are dermatophagoides pteronyssinus (55.4%), dermatophagoides culinae (53.9%), tropical mite (38.3%), dog hair (11.8%), blattella germanica (11.5%) and cat hair (8.1%); that from developing region out of Pearl River Delta are dermatophagoides culinae (50.4%), tropical mite(48.0%), dermatophagoides pteronyssinus (47.2%), blattella germanica (13.4%), cat hair (8.7%) and dog hair (7.1%). There is no significant difference of allergen positivity between the patients from the two regions except tropical mite. The positive rate in 15-18 years old patients was also different in the two groups. The positive rate was highest in the age from 19 to 30 years old,with a decreasing trend in younger and elder patients. There is no significant difference of the allergen positive rate between the both groups with body weight, family history and gender (P > 0.05). A higher allergen positivity was found in the patients with family history (P < 0.05).@*CONCLUSION@#Dermatophagoides pteronyssinus, dermatophagoides culinae, Tropical mite, dog hair, blattella germanica and cat hair are the major allergens in developed region of Pearl River Delta and developing region out of Pearl River Delta in Guangdong, but their ranking has some difference in the two regions. Patients with family history had a higher allergen positive rate.