Use of azacitidine for myelodysplastic syndromes: controversial issues and practical recommendations
Blood Research
; : 87-98, 2013.
Article
en En
| WPRIM
| ID: wpr-74592
Biblioteca responsable:
WPRO
ABSTRACT
Azacitidine is recommended for patients with higher-risk myelodysplastic syndromes (MDS) who are not eligible for intensive therapy or for patients with lower-risk MDS who have thrombocytopenia or neutropenia or have anemia that is unresponsive to other therapies. However, standard treatment with azacitidine has not been optimized and many issues about the use of azacitidine remain unresolved. The use of azacitidine is expanding rapidly, but limited comparative clinical trial data are available to (i) define the optimal use of azacitidine in patients with higher-risk MDS or around the time of allogeneic hematopoietic stem cell transplantation, (ii) identify those patients with lower-risk MDS who may benefit from treatment, and (iii) guide physicians on alternative therapies after treatment failure. Increasing evidence suggests that the clinical features, prognostic factors, and cytogenetic profiles of patients with MDS in Asia differ significantly from those of patients in Western countries, so the aim of this review is to summarize the evidence and provide practical recommendations on the use of azacitidine in patients with MDS in the Republic of Korea. Evidence considered in this review is based on published clinical data and on the clinical experience of an expert panel from the acute myeloid leukemia/MDS Working Party of the Korean Society of Hematology.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Asia
/
Azacitidina
/
Trombocitopenia
/
Síndromes Mielodisplásicos
/
Terapias Complementarias
/
Insuficiencia del Tratamiento
/
Guías de Práctica Clínica como Asunto
/
Trasplante de Células Madre Hematopoyéticas
/
Citogenética
/
República de Corea
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Blood Research
Año:
2013
Tipo del documento:
Article