Objective To investigate the effect of Tongyuan acupuncture therapy on theplatelet activation index in patients with Qi stagnation and blood stasis type during the recovery period of cerebral infarction. Methods A total of 90 cerebral infarction patients with Qi deficiency and blood stasis were admitted in the acupuncture rehabilitation department of Hospital of Traditional Chinese Medicine in Longgang District during April 2017 to December 2017 and were randomly divided into treatment group and control group, each of 45 cases. The control group was treated with conventional western medicine therapy, while the treatment group were treated with Tongyuan acupuncture therapy with the convetional therapy. The Barthel index, NIHSS score and PAF, PAC-1 content were determined and compared before and after treatment in the two groups, meanwhile, the clinical efficacy were staticsed and compared between the two groups. Results The differences of Barthel index (9.5 ± 4.3 vs. 5.6 ± 2.4, t=5.312), the NIHSS score (3.2 ± 0.8 vs. 1.5 ± 0.7, t=10.728) in the treatment group were significantly higher than those in control group (P<0.05). After treatment, the PAC-1 (5.51% ± 1.27% vs. 6.45% ± 1.66%, t=3.067), PAF (157.02 ± 18.22 pg/ml vs. 165.81 ± 17.65 pg/ml, t=2.324) in the treatment group was significantly lower than those in the control group (P<0.05). The curative rate (66.6% vs. 35.6%, χ2=13.611) and the total effective rate (95.6% vs. 64.4%, χ2=8.715) in the treatment group were significantly higher than those in the control group (P<0.05). Conclusions The Tongyuan acupuncture treatment showed the significant curative effect on cerebral infarction qi deficiency and blood stasis patients during the recovery period , and it can improve the ability of daily life, reduce the degree of nerve function defect and the degree of platelet activation.