Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells
Natural Product Sciences
; : 99-102, 2018.
Article
en En
| WPRIM
| ID: wpr-741610
Biblioteca responsable:
WPRO
ABSTRACT
This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 µM increased intracellular dopamine levels at 1 – 24 h. Ombuoside (1, 5, and 10 µM) also significantly increased the phosphorylation of tyrosine hydroxylase (TH) (Ser40) and cyclic AMP-response element binding protein (CREB) (Ser133) at 0.5 – 6 h. In addition, ombuoside (1, 5, and 10 µM) combined with L-DOPA (20, 100, and 200 µM) further increased intracellular dopamine levels for 24 h compared to L-DOPA alone. These results suggest that ombuoside regulates dopamine biosynthesis by modulating TH and CREB activation in PC12 cells.
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Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fosforilación
/
Tirosina 3-Monooxigenasa
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Proteínas Portadoras
/
Dopamina
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Levodopa
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Células PC12
Límite:
Animals
Idioma:
En
Revista:
Natural Product Sciences
Año:
2018
Tipo del documento:
Article