Expressions of IGF-1 and TGF-β1 at different stages of spontaneously hypertensive rats and their relationship with the left ventricular hypertrophy and myocardial fibrosis / 第三军医大学学报
Journal of Third Military Medical University
; (24): 410-412, 2001.
Article
en Zh
| WPRIM
| ID: wpr-736987
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the expression of IGF-1 and TGF-β1 at different stages of hypertension in the spontaneously hypertensive rats (SHR) and their relationship with ventricular hypertrophy and myocardial fibrosis in the left ventricle. Methods The expression of IGF-1 and TGF-β1 mRNA were measured with RT-PCR. Dynamic changes of the left ventricular hypertrophy and myocardial fibrosis were examined by biochemical assay and image analysis. Results Increased expression of IGF-1 was observed from the 14 th to the 24 th week which coincided with the progress of the left ventricular hypertrophy (LVH), but not with that of myocardial fibrosis (MF). No significant change was observed in the expression of TGF-β1 in SHR group when compared with that of control. Conclusion Increased expression of IGF-1 in the left ventricle of SHR is probably associated with the progress of LVH.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Third Military Medical University
Año:
2001
Tipo del documento:
Article