Time-dependent change in expression of type-Ⅰ collagen protein gene during the development of restenosis after arterial injury / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 133-137, 2001.
Article
en Zh
| WPRIM
| ID: wpr-735348
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To observe the alteration of type- Ⅰ collagen protein gene expression after arterial injury and investigate its effect on the development of restenosis. Methods: Firstly, thee xperimental carotid arterial injury rabbit model was constructed. Then, Norther n blot, in situ hybridization and histomorphometric analysis were used to de tect the expression of procollagen mRNA and the accumulation of collagen protein 1,2,4 weeks after injury. Results: Type- Ⅰ collag en mRNA increased 1 week after injury, peaked 2 weeks later and decreased 4 week s later. The deposition of the collagen protein account for a high percentage o f space in neointima on histomorphometric analysis. Conclusion: Collagen protein may play an important role in the development of neointima and restenosis.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Academic Journal of Second Military Medical University
Año:
2001
Tipo del documento:
Article