Study on the pharmacolinetics,tissue distridution and excretion of nerve growsth factof in mice / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 65-67, 2001.
Article
en Zh
| WPRIM
| ID: wpr-735335
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To study the pharmacokinetics,thissue distribution and secretion of nerve growth factor(NGF)in mice.Methods:The conecntration of NGF in various body fluids and tissue were determined by isotope tracer combined SDSPAGE method.Results:The plasma concenmtration-time curve was in accordance with the two-compartment pharmacokinetic model.The elimation half-life(t1/2β)was 3.1.The half-life of distribution(t1/2ka)was 5min.Tpeak was 25 min.AUC was 72.4 mg·kg-1·h-1.The concentrations of NGF were high in thyroid,blood,submaxillary glands,superior cervical ganglion,adrenasl and kidneys.Conclusion:NGF has a wide distribution,high tissue concentrationa nd excrtet mainly through the urine.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Academic Journal of Second Military Medical University
Año:
2001
Tipo del documento:
Article