Effect of intravenous injection of corticosterone on the presympathetic neurons in rostral ventrolateral medulla of rats / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 24-27, 2001.
Article
en Zh
| WPRIM
| ID: wpr-735326
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To study the role of glucocorticoid i n the integration of sympathetic nervous system and cardiovascular activity. Methods: Neurons in the rostral ventrolateral medulla (RVLM) were extracelluarly recorded and identified as the presympathetic neurons of adult rats. The spontaneous discharge of the presympathetic neurons in the RVLM were observed by bolus intravenous injection of corticosterone (50, 100, 150 μg/kg） . Results: The firing rate of 12 presympathetic neurons was incr eased by intravenous application of corticosterone (P<0.05), and this effect showed a dose-dependent manner. The latency of excitatory effect was (104±2 5) s. Conclusion: Corticosterone can rapidly excite the presym pathetic neurons in the RVLM, this action might be involved in the integration o f sympathetic nervous system through the “rapid membrane effects”.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Academic Journal of Second Military Medical University
Año:
2001
Tipo del documento:
Article