Effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and endoplasmic reticulum stress of the cardiac muscle in obese middle-aged rats
The Korean Journal of Physiology and Pharmacology
; : 633-641, 2017.
Article
en En
| WPRIM
| ID: wpr-727951
Biblioteca responsable:
WPRO
ABSTRACT
The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese middle-aged rats. We induced obesity over 6 weeks of period in 40 male Sprague-Dawley rats around 50 weeks old, and were randomly divided into four experimental groups: chow, HFD, exercise+HFD, and exercise+chow. The exercising groups underwent high-intensity intermittent training using a ladder-climbing and weight exercise 3 days/week for a total of 8 weeks. High-fat diet and concurrent exercise resulted in no significant reduction in body weight but caused a significant reduction in visceral fat weight (p<0.05). Expression of PPARδ increased in the exercise groups and was significantly increased in the high-fat diet+exercise group (p<0.05). Among the ER stress-related proteins, the expression levels of p-PERK and CHOP, related to cardiac muscle damage, were significantly higher in the cardiac muscle of the high-fat diet group (p<0.05), and were significantly reduced by intermittent ladder-climbing exercise training (p<0.05). Specifically, this reduction was greater when the rats underwent exercise after switching back to the chow diet with a reduced caloric intake. Collectively, these results suggest that the combination of intermittent ladder-climbing exercise training and a reduced caloric intake can decrease the levels of ER stress-related proteins that contribute to cardiac muscle damage in obesity and aging. However, additional validation is required to understand the effects of these changes on mitochondrial biogenesis during exercise.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Biogénesis de Organelos
/
Peso Corporal
/
Ingestión de Energía
/
Envejecimiento
/
Ratas Sprague-Dawley
/
Dieta
/
Retículo Endoplásmico
/
Grasa Intraabdominal
/
Estrés del Retículo Endoplásmico
/
Dieta Alta en Grasa
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2017
Tipo del documento:
Article