Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs
The Korean Journal of Physiology and Pharmacology
; : 267-274, 2013.
Article
en En
| WPRIM
| ID: wpr-727720
Biblioteca responsable:
WPRO
ABSTRACT
A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage accumulation, interstitial edema, alveolar septal thickness, perivascular fibrosis, and collapse in radiation-treated lungs were inhibited by curcumin administration. Radiation-induced transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin. Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-alpha (TNF-alpha), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2). Curcumin also inhibited the nuclear translocation of nuclear factor-kappa B (NF-kappaB) p65 in radiation-treated lungs. These results indicate that long-term curcumin administration may reduce lung inflammation and fibrosis caused by radiation treatment.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neumonía
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Fibrosis
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Western Blotting
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Colágeno
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Factor de Necrosis Tumoral alfa
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Receptores del Factor de Necrosis Tumoral
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Curcumina
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Edema
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Ciclooxigenasa 2
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Lesión Pulmonar
Límite:
Animals
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2013
Tipo del documento:
Article