Expression of Matrix Metalloproteinases and Their Inhibitors in Squamous Cell Carcinoma of the Tonsil and Their Clinical Significance
Clinical and Experimental Otorhinolaryngology
; : 88-94, 2011.
Article
en En
| WPRIM
| ID: wpr-70193
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES: To investigate expressions of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in squamous cell carcinoma of the tonsil and to correlate expression profiles with clinicopathological characteristics. METHODS: Paraffin blocks were obtained from 45 tonsil squamous cell carcinoma (SCC) patients, who underwent surgery as an initial treatment between 1994 and 2004, and from 20 normal controls. Expressions of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 were investigated immunohistochemically. RESULTS: The expressions of MMPs (except MMP-2) and TIMPs were found to be significantly different in tonsil SCC and normal control tissues. Furthermore, MMP-13 expression was found to be correlated with tumor invasion (P=0.05), and the expressions of MMP-9 and TIMP-1 with nodal metastasis (P=0.048, 0.031). No relation was found between MMP or TIMP expression and recurrence. However, MMP-9 expression was found to be significantly associated with 5-year survival in tonsil SCC patients by multivariate analysis (hazard ratio, 3.853; P=0.013). CONCLUSION: Significant overexpressions of multiple MMPs and TIMPs were found in tonsil SCC tissues. Furthermore, our findings suggest that MMP-9 expression might be a useful prognostic factor.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Parafina
/
Pronóstico
/
Recurrencia
/
Tonsila Palatina
/
Carcinoma de Células Escamosas
/
Análisis Multivariante
/
Inhibidor Tisular de Metaloproteinasa-1
/
Inhibidor Tisular de Metaloproteinasa-2
/
Metaloproteinasas de la Matriz
/
Metaloproteasas
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Clinical and Experimental Otorhinolaryngology
Año:
2011
Tipo del documento:
Article