Research Progress of β-catenin in Chronic Myelogenous Leukemia -Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 600-602, 2018.
Article
en Zh
| WPRIM
| ID: wpr-690943
Biblioteca responsable:
WPRO
ABSTRACT
β-catenin is an important member of Wnt signaling pathway. With more and more research on the relationship between β-catenin and cancers, it is noted that the concentration of β-catenin in cells is not only the landmark of activating the Wnt signaling pathway, but also a common phenomenon in various tumor cells. Moreover, abnormal expression of β-catenin is reported in blastic phase of CML and IM-resistant CML. Besides, β-catenin inhibitor is proved to be effective for the improvement of the IM susceptibility and the postponment of blastic phase. Here is to make a brief review about the mechanisms of β-catenin in the treatment of CML, such as classical signaling pathways as well as new genes and pathways.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Beta Catenina
/
Vía de Señalización Wnt
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2018
Tipo del documento:
Article