A new naphthalene derivative from bulbs of Eleutherine americana / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 3683-3687, 2018.
Article
en Zh
| WPRIM
| ID: wpr-689860
Biblioteca responsable:
WPRO
ABSTRACT
A new naphthalene derivative and three known compounds were isolated from the petroleum ether extract of the bulbs of Eleutherine americana by using various chromatographic techniques, such as column chromatography over silica gel and semi-preparative HPLC. Their structures were elucidated by spectroscopic date (MS, UV, IR, NMR), which were identified as eleutherol B (1), 4,8-dihydroxy-3-methoxy-1-methylanthraquinone-2-carboxylic acid methyl ester (2), 8-hydroxy-3,4-dimethoxy-1-methylanthraquinone-2-carboxylic acid methyl ester (3), and isoeleutherine (4). Compound 1 is a new compound. The diastolic blood vessels activity of compound 1 and 2 were potent, reaching 82.5% and 85.3% at the concentration of 10 μmol·L⁻¹, which were basically the same as that of the positive drug tanshinone ⅡA.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2018
Tipo del documento:
Article