Cefoxitin plus levofloxacin for prevention of severe infection after transrectal prostate biopsy / 中华男科学杂志
Zhonghua nankexue
; Zhonghua nankexue;(12): 322-326, 2018.
Article
en Zh
| WPRIM
| ID: wpr-689757
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>Objective</b>To evaluate the effect of cefoxitin prophylactic in reducing the incidence of severe infection after transrectal prostate biopsy (TRPB).</p><p><b>METHODS</b>This retrospective study included 155 cases of TRPB with a 5-day administration of oral levofloxacin at 200 mg bid (the control group) and another 167 cases with a 3-day administration of oral levofloxacin at the same dose plus intravenous cefoxitin at 2.0 g 2 hours before TRPB (the experimental group) according to the distribution characteristics of drug-resistance bacteria in our department. The patients of the control and experimental groups were aged (68.68 ± 8.12) and (68.72 ± 7.51) years, with PSA levels of (19.78 ± 21.57) and (21.15 ± 42.63) μg/L, involving (11.68 ± 1.44) and (11.77±1.02) biopsy cores, respectively. Comparisons were made between the two groups of patients in the incidence rate of severe infection, which was defined as lower urinary track symptoms plus the systemic inflammatory response syndrome (SIRS) within 7 days after TRPB.</p><p><b>RESULTS</b>The incidence rate of postoperative severe infection was significantly lower in the experimental group than in the control (0.6% ［1/167］ vs 5.8% ［9/155］, P < 0.05). Blood cultures revealed positive E-coli strains in 6 cases in the control group, including 5 ESBL-positive and 4 quinolone-resistant and amikacin-sensitive cases, all sensitive to cefoxitin, cefoperazone/sulbactam and imipenem. The only one case of severe infection was shown to be negative in blood culture.</p><p><b>CONCLUSIONS</b>Preoperative intravenous administration of cefoxitin according to the specific distribution characteristics of drug-resistance bacteria can significantly reduce the incidence of severe infection after TRPB.</p>
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
/
Complicaciones Posoperatorias
/
Próstata
/
Biopsia
/
Sangre
/
Cefoxitina
/
Estudios Retrospectivos
/
Farmacorresistencia Bacteriana
/
Usos Terapéuticos
/
Escherichia coli
Tipo de estudio:
Observational_studies
Límite:
Aged
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua nankexue
Año:
2018
Tipo del documento:
Article