Synthsis of quaternary Ammonium-Glucosamine conjugate / 中国海洋药物
Chinese Journal of Marine Drugs
; (6)2001.
Article
en Zh
| WPRIM
| ID: wpr-683922
Biblioteca responsable:
WPRO
ABSTRACT
Quaternary ammonium glucosamine conjugatewas prepared by a two step procedure.First,condensation of glucosamine hydrochloride with chloro acetic chloride in the presence of potassium bicarbonate in aqueous medium at 0℃ provided the N chloroacetyl derivative in 74% yield.Subsequent reaction of this intermediate with pyridine at 40℃ for 3 days gave the pyridinium conjugate in 71% yield.The structures of compounds were confirmed by IR,NMR spectra and element analysis.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Marine Drugs
Año:
2001
Tipo del documento:
Article