Dihydromyricetin exerted its vasoconstrictive effects by increasing intracellular Ca~(2+) in isolated canine carotid artery / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)2003.
Article
en Zh
| WPRIM
| ID: wpr-680216
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WPRO
ABSTRACT
Aim To investigate the effect of dihydromyricetin on canine carotid artery and the underlying mechanism.Methods The in vitro isometric tension measurement technique was employed to investigate the effect of dihydromyricetin on canine carotid artery rings.Laser scanning confocal microscope technique was used to measure the dynamic change of intracellular calcium concentration in single VSMC.Results Dihydromyricetin(1～300 ?mol?L-1)caused a concentration-dependent contraction of both endothelium-intact and endothelium-denuded rings.This constrictive effect was attenuated in Ca2+-free solution(P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
2003
Tipo del documento:
Article