Effect of verapamil on electrobiological activity and seizure behavior in phenytoin-carbamazepine resistant rats / 中华神经科杂志
Chinese Journal of Neurology
; (12)2001.
Article
en Zh
| WPRIM
| ID: wpr-676281
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WPRO
ABSTRACT
Objective To invesgate the effect of P-glycoprotein(PGP)inhibitor,verapamil,on electrobiological activity and seizure behavior in phenytoin-carbamazepine(PHT-CBZ)resistant rats.Methods The model of medically intractable epilepsy was established by kindling of amygdale. Verapamil was applied to PHT-CBZ resistant rats,followed by the observation on after discharge threshold (ADT),after discharge duration(ADD)and seizure activity.Results Compared with the control group, the ADT was higher in PHT-CBZ resistant rats peritoneally injected with verapamil((238.0?32.2)?A vs (177.0?23.3)?A,P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Neurology
Año:
2001
Tipo del documento:
Article