Immunostimulatory Effects of Silica Nanoparticles in Human Monocytes
Immune Network
; : 94-101, 2013.
Article
en En
| WPRIM
| ID: wpr-67401
Biblioteca responsable:
WPRO
ABSTRACT
Amorphous silica particles, whose applications are increasing in many biomedical fields, are known to be less toxic than crystalline silica. In this study, the inflammatory effects of amorphous silica nanoparticles were investigated using 30-nm amorphous silica nanoparticles and human peripheral blood mononuclear cells (PBMCs) or purified monocytes. As a result, production of IL-1beta and IL-8 were increased. In addition, the mitochondrial reactive oxygen species (ROS) was detected, which may lead to mitochondrial membrane disruption. Most importantly, inflammasome formation was observed. Therefore, these results provide immunological information about amorphous silica nanoparticles and suggest that amorphous silica nanoparticles can evoke innate immune reactions in human monocytes through production of IL-1beta and IL-8.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Monocitos
/
Interleucina-8
/
Especies Reactivas de Oxígeno
/
Dióxido de Silicio
/
Cristalinas
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Membranas Mitocondriales
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Nanopartículas
Límite:
Humans
Idioma:
En
Revista:
Immune Network
Año:
2013
Tipo del documento:
Article