GUARDIX-SL(R) in Sinus Surgery: A Preclinical Animal Study / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 1457-1461, 2005.
Article
en Ko
| WPRIM
| ID: wpr-651629
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: The most frequent complication of FESS (functional endoscopic sinus surgery) is stenosis of the operation site. The complication may influence the postoperative wound healing and the outcome of surgery. There are several measures proposed to prevent the complication. We sought to determine the efficacy of GUARDIX-SL which is made from sodium hyaluronate and sodium carboxymethylcellulose in soluble form. MATERIALS AND METHOD: For 7 rabbits, we made a surgical opening anterior to sinus ostium of the maxillary sinuses on both sides. We put the gelfoams soaked with GUARDIX-SL into the left openings and those soaked with normal saline into the right openings as a control group. We measured the size of the openings after two weeks. RESULTS: There was no synechiae in GUARDIX-SL group whereas we found synechiae developed in two openings in the control group. The mean area of the opening was 9.29 mm2 and 1.61 mm2 in GUARDIX-SL group and the control group (p=0.027), respectively. CONCLUSION: GUARDIX-SL was effective in reducing postoperative stenosis in the animal model.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Cicatrización de Heridas
/
Carboximetilcelulosa de Sodio
/
Constricción Patológica
/
Modelos Animales
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Esponja de Gelatina Absorbible
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Ácido Hialurónico
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Seno Maxilar
Límite:
Animals
Idioma:
Ko
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
2005
Tipo del documento:
Article