Expression of vascular endothelial growth factor and cyclooxygenase-2 in laryngeal squamous cell carcinoma and its significance / 华中科技大学学报（医学）（英德文版）
J. huazhong univ. sci. tech. med. sci
; (6): 105-7, 2006.
Article
en En
| WPRIM
| ID: wpr-634309
Biblioteca responsable:
WPRO
ABSTRACT
In order to study the expressions of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in human laryngeal squamous cell carcinoma (LSCC) and its significance, the expression of VEGF mRNA and COX-2 mRNA in 62 cases of LSCC and 54 adjacent noncancerous laryngeal tissues and 9 normal human laryngeal mucous tissues was detected by using techniques of semi-quantitative RT-PCR. It was found that the expression level of VEGF and COX-2 mRNA was significantly increased in LSCC as compared with that in the normal human laryngeal mucous tissues (both P < 0.01), and the expression level of VEGF and COX-2 mRNA were significantly increased in stage Ill + IV tissues of LSCC as compared with the stage I + II tissues of LSCC (P < 0.01). There was a high positive correlation between VEGF and COX-2 expression in LSCC (r = 0.756, P < 0.01). These data raise the possibility that VEGF and COX-2 may play key roles in the growth, invasion and metastasis of LSCC.
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Base de datos:
WPRIM
Asunto principal:
ARN Mensajero
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Carcinoma de Células Escamosas
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Biomarcadores de Tumor
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Neoplasias Laríngeas
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Factor A de Crecimiento Endotelial Vascular
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Ciclooxigenasa 2
Idioma:
En
Revista:
J. huazhong univ. sci. tech. med. sci
Año:
2006
Tipo del documento:
Article