Hypertriglyceridemia and Cardiovascular Diseases: Revisited
Korean Circulation Journal
; : 135-144, 2016.
Article
en En
| WPRIM
| ID: wpr-62942
Biblioteca responsable:
WPRO
ABSTRACT
Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid profiles and cardiovascular outcomes. In this review, we will discuss the role of hypertriglyceridemia, triglyceride-rich lipoproteins and remnant cholesterol on cardiovascular disease, and the potential implications for treatment stargeting hypertriglyceridemia.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Triglicéridos
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Enfermedades Cardiovasculares
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Hipertrigliceridemia
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Estudios Epidemiológicos
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Ácidos Grasos Omega-3
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Colesterol
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Factores de Riesgo
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Inhibidores de Hidroximetilglutaril-CoA Reductasas
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Apolipoproteína C-III
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Ácidos Fíbricos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Korean Circulation Journal
Año:
2016
Tipo del documento:
Article