Synthesis and inhibition of NO production activities of 1,6-O, O-diacylbritannilactone derivatives / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 440-444, 2017.
Article
en Zh
| WPRIM
| ID: wpr-615033
Biblioteca responsable:
WPRO
ABSTRACT
Eight 1,6-O,O-diacetylbritannilactone (OABL) derivatives (compounds 1-8) were synthesized by esterification or reduction of 1-O-diacetylbritannilactone (ABL) isolated from Inula japonica.All derivatives were evaluated for their anti-inflammation activities through the determination of inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophages.As results,compounds 5-8 (IC50 ＜ 2 μmol/L) exhibited more potent inhibition of NO production activities than the lead compound OABL.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of China Pharmaceutical University
Año:
2017
Tipo del documento:
Article