Current status of standards for laboratory diagnosis of pertussis and clinical relevance of serological diagnosis / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 560-564, 2017.
Article
en Zh
| WPRIM
| ID: wpr-611502
Biblioteca responsable:
WPRO
ABSTRACT
Despite high coverage of vaccinations, incidence of pertussis (whooping cough) has been increasing throughout the world and large outbreaks were reported in several countries.Adolescents and adults with atypical pertussis symptoms have become the main sources of infants′ pertussis.Since clinicians are lack of experience in making diagnosis based on atypical symptoms, laboratory methods are needed.The currently recommended laboratory methods include bacterial culture, PCR and serology ELISA.It is well known that sensitivity and specificity of the above-mentioned methods may vary depending on many factors such as status of vaccination, timing of specimen collection and onset of symptoms.Serology ELISA to measure specific anti-pertussis toxin IgG antibodies in serum has been proven to be one suitable method for the diagnosis of pertussis infection in adolescents and adults.In this review, we summarize the current status of methods used in China and other countries for the laboratory diagnosis of pertussis and discuss the clinical relevance of serology ELISA for pertussis diagnosis.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Diagnostic_studies
/
Guideline
Idioma:
Zh
Revista:
Chinese Journal of Microbiology and Immunology
Año:
2017
Tipo del documento:
Article