Evaluation of the value of resting state BOLD-fMRI in radiation-induced brain injury after nasopharyngeal carcinoma radiotherapy / 实用放射学杂志
Journal of Practical Radiology
; (12): 1352-1356, 2017.
Article
en Zh
| WPRIM
| ID: wpr-607353
Biblioteca responsable:
WPRO
ABSTRACT
Objective To analyze the value of resting state BOLD-fMRI in the early diagnosis of brain injury after nasopharyngeal carcinoma radiotherapy.Methods Four groups of nasopharyngeal carcinoma patients,including before radiotherapy group (G0),0-3 months after radiotherapy group (G1), 3-6 months after radiotherapy group (G2) and 6-9 months after radiotherapy group (G3),were underwent a resting state BOLD-fMRI scan, and Matlab software DPARSF tool was used to analyze and postprocess the data based on G1-G0,G2-G0,G3-G0,G2-G1,G3-G2 and G3-G1.Results Compared with the G0 group,the activity of bilateral hippocampus and temporal lobes was decreased in G1 and G2 groups,and the decreased degree in G2 group was smaller than that in G1 group.Compared with G1 group,brain metabolic activity increased in G2 and G3 group,but did not return to the initial level before radiotherapy.Conclusion Abnormal changes of resting state BOLD-fMRI have an important clinical significance in early diagnosis of radiation-induced brain injury after nasopharyngeal carcinoma radiotherapy.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Screening_studies
Idioma:
Zh
Revista:
Journal of Practical Radiology
Año:
2017
Tipo del documento:
Article