Screening of the nucleotide sequences affected by α-synuclein in vitro / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1225-1228,1229, 2014.
Article
en Zh
| WPRIM
| ID: wpr-599748
Biblioteca responsable:
WPRO
ABSTRACT
Aim To study the screening of the nucleo-tide sequences might be affected by α-syn in vitro. Methods The nucleotide sequences were synthesized according to the feature of base composition, and then mixed with the α-syn-GFP. The CD was used to ana-lyse the changes of the peak. Result The peak of the CD changed greatly when the α-syn-GFP mixed with the GC-box like sequence. Conclusion The α-syn-GFP might affect the GC-box like sequence after trans-located into the nuclei. Then, it plays a role in physio-logical and pathological conditions by affecting the reg-ulation of gene expression.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
2014
Tipo del documento:
Article