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Relationship Between Obesity and N-Terminal Brain Natriuretic Peptide Level as a Prognostic Value After Acute Myocardial Infarction
Seon-Gyu CHOI; Myung-Ho JEONG; Youngkeun AHN; Jeong-Gwan CHO; Jung-Chaee KANG; Shung-Chull CHAE; Seung-Ho HUR; Taek-Jong HONG; Young-Jo KIM; In-Whan SEONG; Jei-Keon CHAE; Jay-Young RHEW; In-Ho CHAE; Myeong-Chan CHO; Jang-Ho BAE; Seung-Woon RHA; Chong-Jin KIM; Donghoon CHOI; Yang-Soo JANG; Junghan YOON; Wook-Sung CHUNG; Ki-Bae SEUNG; Seung-Jung PARK.
Korean Circulation Journal ; : 558-564, 2010.
Article en En | WPRIM | ID: wpr-59735
Biblioteca responsable: WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. SUBJECTS AND METHODS: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. RESULTS: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393+/-4,022 pg/mL in the lean group (n=875), 1,506+/-3,074 pg/mL in the overweight group (n=724) and 1,100+/-1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). CONCLUSION: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.
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Texto completo: 1 Base de datos: WPRIM Asunto principal: Fragmentos de Péptidos / Encéfalo / Índice de Masa Corporal / Factores de Riesgo / Estudios de Seguimiento / Péptido Natriurético Encefálico / Sobrepeso / Síndrome Coronario Agudo / Insuficiencia Cardíaca / Corea (Geográfico) Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Korean Circulation Journal Año: 2010 Tipo del documento: Article
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Texto completo: 1 Base de datos: WPRIM Asunto principal: Fragmentos de Péptidos / Encéfalo / Índice de Masa Corporal / Factores de Riesgo / Estudios de Seguimiento / Péptido Natriurético Encefálico / Sobrepeso / Síndrome Coronario Agudo / Insuficiencia Cardíaca / Corea (Geográfico) Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Korean Circulation Journal Año: 2010 Tipo del documento: Article