Cloning and Identification of Promoter of Human LCRG1 Gene / 生物化学与生物物理进展
Progress in Biochemistry and Biophysics
; (12)2006.
Article
en Zh
| WPRIM
| ID: wpr-591926
Biblioteca responsable:
WPRO
ABSTRACT
Laryngeal carcinoma related gene 1(LCRG1) is a candidate tumor suppressor gene of Laryngeal carcinoma. To further investigate its transcriptional regulation, the transcriptional start sites for LCRG1 gene have been identified by 5′ RACE (rapid amplification of cDNA ends) based on the bioinformation analysis of LCRG1. Then eleven luciferase expression vectors which contained potential human LCRG1 gene promoter were constructed. Luciferase reporter assay indicated that LCRG1 promoter region was mainly located in -169～+127 region nearby the major transcriptional start site. These results suggested that the region (-169～+127) includes an essential promoter for human LCRG1 gene transcription.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Diagnostic_studies
Idioma:
Zh
Revista:
Progress in Biochemistry and Biophysics
Año:
2006
Tipo del documento:
Article