Effects of chronic mthylmercury chloride exposure on activity of protein kinase C in rat cerebellum during development / 吉林大学学报(医学版)
Article
en Zh
| WPRIM
| ID: wpr-586627
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WPRO
ABSTRACT
Objective To study the effects of methylmercury chloride(MMC) on protein kinase C(PKC) activities in rat developing cerebellum.Methods The animals in experimental groups were fed standard rat chow with(0.75 mg) MMC(ExpⅠ),1.5 mg MMC(ExpⅡ) and 3.0 mg MMC(ExpⅢ)respectively for 90 d before gestation to(30 d) post parturition.Cerebella of pups from each group on postnatal days(PND) 3,7,17,21 and 30 were dissected. All the samples were separated into cytosol and membrane subcellular fractions and assayed for PKC activity by the improved method from Takai′s.Results Membrane and cytosolic PKC activities of pups′ cerebella from certain experimental groups were significantly higher than those of corresponding control group,PKC activities of rats from ExpⅡ,ExpⅢ and PND 3,7,14 in ExpⅠwere significantly higher than those in control group((P
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1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Jilin University(Medicine Edition)
Año:
2006
Tipo del documento:
Article