L-arginine attenuates proten expression of related cell cycle regulatory factors in rats after balloon injury / 中国介入心脏病学杂志
Chinese Journal of Interventional Cardiology
; (4)1993.
Article
en Zh
| WPRIM
| ID: wpr-582103
Biblioteca responsable:
WPRO
ABSTRACT
Objective To determine whether the anti-proliferation effect of L-arginine is due to inhibiting the expression of cyclin dependent kinase-2 (CDK2)、 CyclinE and proliferation cell nuclear antigen (PCNA) in blood vessel after balloon injury. Methods Rats were randomized into three groups: Group S (sham operation group), Group C (balloon injury control group) and Group L (balloon injury + L-arginine group). After 14 days, blood samples were collected for biochemical studies, and the thoracic aortas were harvested for immunohistochemistry. The expression of CDK2、 CyclinE and PCNA were measured by means of computer image analayzer. Results The levels of plasma nitric oxide (NO) in group C were significantly lower than those in group S. Compared with group C, the levels of plasma NO increased (P
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Base de datos:
WPRIM
Tipo de estudio:
Clinical_trials
Idioma:
Zh
Revista:
Chinese Journal of Interventional Cardiology
Año:
1993
Tipo del documento:
Article